Time-dependent exacerbation of amphetamine4nduced taste aversions following exposure to footshock

Please be advised that this information was generated on 2016-05-01 and may be subject to change. A bstract Previous studies have shown that stressors at­ tenuate LiCl-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies ex­ amined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA. Experiment 1 demonstrated that exposure to 30 footshocks between saccharin consumption and amphetamine injections did not alter either the acquisition or the extinction of am-phe tain ine-CTA. Experiment 2 demonstrated that expo­ sure to the same shock parameters 2 and 4 days before saccharin-amphetamine pairing increased the magnitude of amphetamine-CTA after one saccharin-amphetamine pairing and delayed the recovery from the CTA. Experi­ ment 2 also demonstrated that footshock increased the initial neophobic response to novel saccharin but did not alter subsequent saccharin consumption among saline-in­ jected animals. These results indicate that stress-induced facilitation of amphetamine CTA are time-dependent and contrast with reports that stressors attenuate LiCl CTA. They also add support to the contention that CTAs in­ duced by self-administered drugs like amphetamine are qualitatively different from CTAs induced by toxic sub­ stances like LiCL.